C3′-endo-puckered pyrrolidine containing PNA has favorable geometry for RNA binding: novel ethano locked PNA (ethano-PNA)
A Banerjee, VA Kumar - Bioorganic & medicinal chemistry, 2013 - Elsevier
A novel peptide nucleic acid (PNA) analogue is designed with a constraint in the aminoethyl
segment of the aegPNA backbone so that the dihedral angle β is restricted within 60–80°,
compatible to form PNA: RNA duplexes. The designed monomer is further functionalized
with positively charged amino-/guanidino-groups. The appropriately protected monomers
were synthesized and incorporated into aegPNA oligomers at predetermined positions and
their binding abilities with cDNA and RNA were investigated. A single incorporation of the …
segment of the aegPNA backbone so that the dihedral angle β is restricted within 60–80°,
compatible to form PNA: RNA duplexes. The designed monomer is further functionalized
with positively charged amino-/guanidino-groups. The appropriately protected monomers
were synthesized and incorporated into aegPNA oligomers at predetermined positions and
their binding abilities with cDNA and RNA were investigated. A single incorporation of the …
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